Non-traditional Route for Three Antifungal Drugs in Fungal Keratitis Treatment

Main Article Content

Christine R Sedhom
Mohamed S Abdel-Rahman
Mohamed S Hussein

Abstract

Aims: This study aims to evaluate the efficacy of the intrastromal route of antifungal drugs in treatment of fungal keratitis.


Study Design:  Prospective non-controlled (single arm) interventional clinical study Place and Duration of Study: Ophthalmology Department, Assiut University Hospital, between March 2016 to November 2017.


Methodology: Corneal scrapings for direct smears and cultures were done for eighteen eyes of 18 consecutive patients and intrastromal injections were given according to sensitivity results.


Results: After one month of follow up of the cases in this study, 33.3% of the cases had rapid complete cure and the rest had incomplete cure with resolution of ulcer sizes by 55.34% ±6.78 after one or more intrastromal injection of antifungal drugs.


Conclusion: Intrastromal injection of antifungal drugs in treatment of fungal keratitis shows promising results in advanced cases of fungal keratitis when combined with the topical route.

Keywords:
Fungal keratitis, intrastromal injection, antifungal drugs, fluconazole, amphotericin B, voriconazole.

Article Details

How to Cite
Sedhom, C., Abdel-Rahman, M., & Hussein, M. (2019). Non-traditional Route for Three Antifungal Drugs in Fungal Keratitis Treatment. Ophthalmology Research: An International Journal, 10(2), 1-11. https://doi.org/10.9734/or/2019/v10i230104
Section
Original Research Article

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