Non-traditional Route for Three Antifungal Drugs in Fungal Keratitis Treatment

Main Article Content

Christine R Sedhom
Mohamed S Abdel-Rahman
Mohamed S Hussein


Aims: This study aims to evaluate the efficacy of the intrastromal route of antifungal drugs in treatment of fungal keratitis.

Study Design:  Prospective non-controlled (single arm) interventional clinical study Place and Duration of Study: Ophthalmology Department, Assiut University Hospital, between March 2016 to November 2017.

Methodology: Corneal scrapings for direct smears and cultures were done for eighteen eyes of 18 consecutive patients and intrastromal injections were given according to sensitivity results.

Results: After one month of follow up of the cases in this study, 33.3% of the cases had rapid complete cure and the rest had incomplete cure with resolution of ulcer sizes by 55.34% ±6.78 after one or more intrastromal injection of antifungal drugs.

Conclusion: Intrastromal injection of antifungal drugs in treatment of fungal keratitis shows promising results in advanced cases of fungal keratitis when combined with the topical route.

Fungal keratitis, intrastromal injection, antifungal drugs, fluconazole, amphotericin B, voriconazole.

Article Details

How to Cite
Sedhom, C., Abdel-Rahman, M., & Hussein, M. (2019). Non-traditional Route for Three Antifungal Drugs in Fungal Keratitis Treatment. Ophthalmology Research: An International Journal, 10(2), 1-11.
Original Research Article


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