The Relationship of HLA-B27 and HLA-B51 on Non-Behcet Uveitis
Ercument Cavdar
Department of Ophthalmology, Kemalpasa State Hospital, Izmir, Turkey
Abdullah Ozkaya
Department of Ophthalmology, Beyoğlu Eye Training and Research Hospital, Istanbul, Turkey
Hande Mefkure Ozkaya
Department of Ophthalmology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
Sınan Bılgın *
Department of Ophthalmology, Sıfa Hospital, Izmir, Turkey
Ozge Elmastas Gultekin
Faculty of Statistics, Ege University, Izmir, Turkey
Mustafa Alparslan Babayigit
Department of Public Health, Gulhane Military Medical Academy, Ankara, Turkey
*Author to whom correspondence should be addressed.
Abstract
Aims: The aim of this study was to investigate the relationship of human leukocyte antigen (HLA)-B27 and HLA-B51 on the clinical characteristics, demographic features, localization, laterality, treatment modalities and visual prognosis in non-Behcet uveitis patients
Study Design: Retrospective study.
Place and Duration of Study: Tepecik Eye Training and Research Hospital. January 1999 and March 2009.
Methodology: A total of 143 non-Behcet uveitis patients were included. Socio-demographic data and clinical features of the patients were reviewed. The patients were divided into four groups according to HLA-B27 and B-51 positivity which were as follows; HLA B-27 (-) B-51 (-), HLA B-27 (+) B-51 (-), HLA B-27 (-) B-51 (+), and HLA B-27 (+) B-51 (+) groups.
Results: Bilateral uveitis and posterior uveitis were more frequent in males in HLA-B27 (+) B51 (+) group, the baseline BCVA values were significantly lower in HLA-B27 (+) B51 (+) group, and also systemic steroid and immunosuppressive treatment were more frequently required to control uveitis attacks in this group. Anterior uveitis was more frequent in the HLA-B27 (-) B51 (-), and HLA-B27 (+) B51 (-) group.
Conclusion: The positivity of both HLA-B27 and HLA-B51 was related with worse visual outcomes in non-Behcet uveitis patients associated with requirement of more aggressive treatment. The negativity of both HLA-B27 and HLA-B51 seemed to be related with better visual outcomes and less number of attacks in non-Behcet uveitis patients.
Keywords: Behcet disease, human leukocyte antigen, uveitis