Primary Orbital Lymphoma – A Rare Challenging Diagnostic Entity

Main Article Content

Nisha Marwah
Niti Dalal
Manali Satiza
Sunita Singh

Abstract

The diagnosis of lymphoproliferative disorder of orbit is quite challenging as both Pseudolymphomas and Non‑Hodgkin’s lymphomas can occur in orbit. Primary orbital lymphoma is a rare entity comprising of 1-2% of Non‑Hodgkin’s lymphoma, majority of them are B‑cell type. It is a slow growing tumor. It presents in the age group of 50–70 years, with a slight female preponderance. Proptosis is the most common presentation. We, herein, report a case of 48 years old male presenting with right non-axial proptosis, watering of eye, blurring of vision and redness for the last 9 months. After thorough clinical and radiological evaluation, a biopsy was taken for histopathological examination. A primary diagnosis of Lymphoproliferative Disorder was made. Following this, a panel of immunohistochemical markers was applied and a final diagnosis of Non-Hodgkin Lymphoma, B-cell type was given.

Keywords:
Primary, non hodgkin’s lymphoma, B cell type, orbit.

Article Details

How to Cite
Marwah, N., Dalal, N., Satiza, M., & Singh, S. (2020). Primary Orbital Lymphoma – A Rare Challenging Diagnostic Entity. Ophthalmology Research: An International Journal, 13(4), 18-21. https://doi.org/10.9734/or/2020/v13i430174
Section
Case study

References

Gaag RVD, Koornneef L, Heerde PV, Vroom PM, Pegels JH, Feltkamp CA, Peeters HJF, Gillissen JPF, Bleeker GM, Feltkamp YEW. Lymphoid proliferations in the orbit: malignant or benign?. British J Ophthal. 1984;68:892-900.

Nicholas H. Andrew NH, Coupland SE, Pirbhai A, Selva D. Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical pathologic review. Survey ophthalmol. 2016;61;778-90.

Qu X-L, Hei Y, Kang L, Yang X-J, Wang Y, Lu X-Z, et al. Establishment of a combination scoring method for diagnosis of ocular adnexal lymphoproliferative disease. PLoS ONE. 2017.12(5):e0160175.

Margret Sigurdardottir M, Sigurdsson H, Barkardottir RB, Kristjansdottir S, Agnarsson BA. Lymphoid tumours of the ocular adnexa: a morphologic and genotypic study of 15 cases. Acta Ophthalmol Scand. 2003:81;299–303.

Yadav BS, Sharma SC. Orbital lymphoma: Role of radiation. Indian J Ophthalmol. 2009;57:91-7.

Borkar AU, Jain K, Jain VK. A large primary orbital lymphoma with proptosis: A case report and review. SurgNeurol Int. 2018;9:249.

Kamal S, Kaliki S. Ocular Adnexal Lymphoma: Clinical Presentation, Diagnosis, Treatment and Prognosis. J Mol Biomark Diagn. 2017;8:312. DOI: 10.4172/2155-9929.1000312

Sriram PR. A rare case of aggressive, huge primary orbital lymphoma with intracranial extension and bone invasion. Asian J Neurosurg. 2017;12:766-8.

Purohit BS, Vargas MI, Ailianou A, Merlini L, Poletti PA, Platon A, et al. Orbital tumours and tumour-like lesions: exploring the armamentarium of multiparametric imaging. Insights Imaging. 2016:7:43–68.

Yuen SJ, Rubin PA. Idiopathic orbital inflammation: distribution, clinical features, and treatment outcome. Arch Ophthalmol. 2003;121:491–99.

Vallinayagam M, Krishnamoorthy J, Vijayakumar L, Suryawanshi D. Bilateral Primary Orbital Non-Hodgkin’s Lymphoma Masquerading AsMyositic Pseudotumor In An Elderly patient. Delhi J Ophthalmol. 2017;28;41-2.

Ghartimagar D, Ghosh A, Shrestha MK, Karki S, Shrestha S, Thapa S, Talwar OP. Orbital lymphoma in an elderly patient. J Pathol Nepal. 2017;7:1124-6.