Exploring Lipid Abnormalities in Senile Cataract: A Cross-Sectional Investigation
Harshal Sahare
Department of Ophthalmology, T.N.M.C and B.Y.L. Nair Hospital, Mumbai, India.
Amit Barapatre
Department of Biochemistry, T.N.M.C and B.Y.L. Nair Hospital, Mumbai, India.
Meeta Piyush Shah
Laboratory Technician, Bai Gulbai Municipal Dispensary G North, Mumbai, India.
Shubhada Girish Vengurlekar *
Laboratory Technician,45 BDD Municipal Dispensary G South, Mumbai, India.
Kalpana Ganesh Kinage
Laboratory Technician, Drug Deaddiction Centre, Psychiatry Department, Seth GSMC and KEMH Parel Mumbai, India.
Santosh Shivpal Pathare
Department of Physiology, Laboratory Technician, Seth GSMC and KEMH Parel Mumbai, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Age-related cataracts (ARC) are a common cause of vision impairment in older adults. Previous studies have suggested that abnormal Lipid profile and oxidative stress may contribute to the development and progression of ARC.
Aim: The aim of this study was to compare the serum Lipid profile levels in patients with ARC and healthy controls.
Materials and Methods: This was a case-control study involving 50 patients with ARC and 50 age and gender-matched controls. Serum Lipid profile levels were measured using standard methods. The data were analyzed using t-test. A P-value of less than 0.05 was considered statistically significant.
Results: The results showed that the mean serum level of HDL Cholesterol was significantly lower in the ARC group than in the control group, while the mean serum level of triglyceride was significantly higher in the ARC group than in the control group.
Conclusion: This study indicates that altered lipid profile may be a risk factor for ARC.
Keywords: Age-related cataract, serum lipid, case-control study, low-density lipoprotein cholesterol