Non-traditional Route for Three Antifungal Drugs in Fungal Keratitis Treatment
Christine R Sedhom *
Department of Ophthalmology, Assiut University Hospital, Assiut, 71516; Egypt.
Mohamed S Abdel-Rahman
Department of Ophthalmology, Assiut University Hospital, Assiut, 71516; Egypt.
Mohamed S Hussein
Department of Ophthalmology, Assiut University Hospital, Assiut, 71516; Egypt.
*Author to whom correspondence should be addressed.
Abstract
Aims: This study aims to evaluate the efficacy of the intrastromal route of antifungal drugs in treatment of fungal keratitis.
Study Design: Prospective non-controlled (single arm) interventional clinical study Place and Duration of Study: Ophthalmology Department, Assiut University Hospital, between March 2016 to November 2017.
Methodology: Corneal scrapings for direct smears and cultures were done for eighteen eyes of 18 consecutive patients and intrastromal injections were given according to sensitivity results.
Results: After one month of follow up of the cases in this study, 33.3% of the cases had rapid complete cure and the rest had incomplete cure with resolution of ulcer sizes by 55.34% ±6.78 after one or more intrastromal injection of antifungal drugs.
Conclusion: Intrastromal injection of antifungal drugs in treatment of fungal keratitis shows promising results in advanced cases of fungal keratitis when combined with the topical route.
Keywords: Fungal keratitis, intrastromal injection, antifungal drugs, fluconazole, amphotericin B, voriconazole.